Changes and significance of serum anti-CCP antibody,MMP-3,IL-17,IL-18 levels in patients with rheumatoid arthritis
10.3969/j.issn.1673-4130.2014.20.006
- VernacularTitle:类风湿关节炎患者血清 ACCP 抗体、MMP-3、IL-17、IL-18的水平变化及意义
- Author:
Ximing ZHENG
;
Yunxia YU
;
Aijun ZHANG
;
Jian CHEN
;
Wei JIA
;
Guangxian XU
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
anti-cyclic citrullinated peptide antibody;
matrix metalloproteinase-3;
interleukin-17;
interleukin-18
- From:
International Journal of Laboratory Medicine
2014;(20):2734-2736
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and significance of serum anti-CCP (ACCP)antibody,matrix metalloprotein-ase-3 (MMP-3 ),interleukin-17 (IL-17 ),interleukin-18 (IL-18 )in the patients with rheumatoid arthritis (RA).Methods The ELISA method was adopted to detect the in the peripheral blood serum ACCP antibody,MMP-3,IL-17 and IL-18 in 80 patients with RA,32 patients with osteoarthritis (OA)and 32 cases of healthy controls and the detection results were performed the statis-tical analysis.Results The ACCP antibody,MMP-3,IL-17 and IL-18 levels in the RA group were significantly higher than those in the OA group and the healthy control groups;the ACCP antibody,MMP-3,IL-17 and IL-18 levels in the low,middle and high RA activity groups were higher than those in the stable group,the ACCP antibody,MMP-3,IL-17,IL-18,disease activity score (DAS28),C-reactive protein (CRP)and erythrocyte sedimentation rate(ESR)in the RA group were increased;the MMP-3,IL-17, IL-18 and DAS28 in the ACCP antibody positive group were higher than those in the A CCP antibody negative group;the positive correlation existed among the ACCP antibody,MMP-3,IL-17 and IL-18 in the RA group (P <0.05);the ACCP antibody,MMP-3, IL-17 and IL-18 were positively correlated with the monitoring indicators of CRP and DAS28 in the low,middle and high RA activi-ty groups.Conclusion MMP-3,IL-17 and IL-18 participate in the occurrence and development process of RA;The detection of ser-um ACCP antibody,MMP-3,IL-17 and IL-18 has a certain value in the judgment of disease activity,and prevention and treatment in the patients with RA.
