ERCC1 gene polymorphism in gastric cancer
10.3760/cma.j.issn.1673-422X.2014.09.008
- VernacularTitle:ERCC 1基因多态性在胃癌中的研究
- Author:
Yuan TIAN
;
Zezhi SHAN
;
Jiayuan PENG
;
Yu WANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Polymorphism,single nucleotide;
ERCC1
- From:
Journal of International Oncology
2014;(9):666-668
- CountryChina
- Language:Chinese
-
Abstract:
As a crucial part of the DNA damage repair process,the expression of excision repair cross-complementing group 1 (ERCC1 )is closely related to the genesis and development of gastric cancer.Studies find that ERCC1 gene polymorphism can alter the expression of the gene itself,which affects the sensitivity and efficacy of platinum-based chemotherapy.Therefore,the detection of ERCC1 polymorphism may guide the indi-vidualized chemotherapy of the patients with gastric cancer.
