Expression and significance of MYC/BCL2 protein coexpression in diffuse large B-cell lymphoma

VernacularTitle:弥漫性大B细胞淋巴瘤中MYC／BCL2蛋白共表达及其意义分析
Author: Jianchen FANG ; Zheng LI ; Zhaoxia XIA ; Huizhi ZHANG
Publication Type:Journal Article
Keywords: Lymphoma,large B-cell,diffuse; Proto-oncogene proteins c-myc; BCL2 protein
From: Journal of International Oncology 2014;(9):712-714
CountryChina
Language:Chinese
Abstract: Objective To explore the condition of MYC/BCL2 protein coexpression in 245 patients with diffuse large B-cell lymphoma (DLBCL)and to find the correlations among MYC/BCL2 protein coexpres-sion,the germinal center B-cell-like (GCB)subtype and non-GCB subtype.Methods Paraffin-embedded lymphoma samples from 245 patients with DLBCL were studied using immunohistochemistry for MYC,BCL2, CD10,BCL6,MUM1 and KI67.And the protein expressions of them were analyzed.Results In the speci-mens of 245 patients with DLBCL,the patients with non-GCB were 163 (66.5%),and the patients with GCB were 82 (33.5%).The group of MYC/BCL2 protein coexpression comprised 35.9% (88/246)of the all patients.Non-GCB subtype group had a significantly higher frequency of MYC/BCL2 protein coexpression than the GCB subtype group (41.7%∶24.4%;χ2 =7.116,P=0.008).Conclusion The data shows that MYC/BCL2 protein coexpression occurs significantly more commonly in the non-GCB subtype.We can predict prog-nosis and choose therapeutic regimen base on the assessment for MYC and BCL2 protein expression.