Expression and regulatory mechanism of microRNA-133 in tumor
10.3760/cma.j.issn.1673-422X.2014.09.001
- VernacularTitle:微小RNA-133在肿瘤中的表达及调控机制
- Author:
Yue ZHANG
;
Liang ZHAO
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Neoplasms;
Neoplasm metastasis;
Signal transduction
- From:
Journal of International Oncology
2014;(9):641-644
- CountryChina
- Language:Chinese
-
Abstract:
As small non-coding RNAs,microRNAs (miRNAs)have been recognized as important reg-ulatory factors in the post-transcription regulation network.Studies have shown that miR-133a and miR-133b, as members of miR-133 family,can regulate the expression of target genes such as epidermal growth factor receptor and oncogene.They regulate the mitogen-activated protein kinases and protein kinase B signaling path-ways,which affect tumor cell proliferation,invasion and migration.MiR-133 plays a key role in the process of tumor development and progression,suggesting that it could be served as a new target for cancer treatment.
