Alternative splicing of tumor associated genes messenger RNA and application
10.3760/cma.j.issn.1673-422X.2014.09.003
- VernacularTitle:肿瘤基因信使RNA可变剪接及其应用
- Author:
Xintong ZHANG
;
Wentao YUE
- Publication Type:Journal Article
- Keywords:
Neoplasms;
RNA,messenger;
Alternative splicing
- From:
Journal of International Oncology
2014;(9):648-651
- CountryChina
- Language:Chinese
-
Abstract:
As a way of gene modification,alternative splicing is an important factor of eukaryotic gene expression and regulation.It makes various transcripts from one protein-coding gene,and greatly extends the genetic information.Alternative splicing of pre-messenger RNA plays an important role in tumor cells.By alter-native splicing,some important genes can generate splicing variants different from those in normal cells.The existence of tumor-specific splicing variants leads to the occurrence and progression of tumor.Therefore,explo-ration on the alternative splicing of tumor-associated genes may be of great significance in tumor diagnosis and treatment.
