Development and differentiation of B cells and autoimmune diseases
10.3760/cma.j.issn.2095-428X.2014.21.004
- VernacularTitle:B淋巴细胞的分化发育与自身免疫性疾病
- Author:
Xuemei TANG
- Publication Type:Journal Article
- Keywords:
B cell;
CD5+B1 cell;
Regulatory B cell;
B10 cells;
Autoimmune diseases
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(21):1611-1613
- CountryChina
- Language:Chinese
-
Abstract:
Of B cells derived from bone marrow hematopoictic stem cells,bone marrow (poultry,as the bursa of fabricius) is a place of B cells development and mature.The growth of B cells can experience from progenitor cell B,pre-B cells,immature B ceils and mature B cells stages in the bone marrow.The differentiation process of B cells can be divided into antigen independ stage and antigen depend stage.CD5 + B1 cells and B10 cells of B cell subsets probably associated with autoimmune disease,B1 cells may play roles of promotion in inflammatory reaction,and B10 cells may suppress autoimmune inflammation.
