Advances in Study on NLRP3 in Autoimmune Diseases
10.3969/j.issn.1008-7125.2015.07.015
- VernacularTitle:NLRP3在自身免疫性疾病中的研究进展
- Author:
Mengyou ZENG
;
Qiaoyun TONG
;
Tingting ZHOU
- Publication Type:Journal Article
- Keywords:
Inflammasomes;
NLRP3;
Caspase 1;
Autoimmune Disease;
Crohn Disease
- From:
Chinese Journal of Gastroenterology
2015;(7):442-444
- CountryChina
- Language:Chinese
-
Abstract:
Inflammasome is a multi-protein complex which plays an important role in innate immune defense,and can adjust the activation of caspase-1 and promote the production of cytokines. NLRP3 is an important member of inflammasome Nod-like receptor(NLR)family,and its activation and expression occur mainly in macrophages and dendritic cells. NLRP3 can sense the pathogen associated molecular patterns(PAMPs)and damage associated molecular patterns(DAMPs)and initiate the inherent immune response,which plays an important role in the pathogenesis of autoimmune diseases. This article reviewed the advances in study on NLRP3 in autoimmune diseases.
