Exploration and Discussion on Mechanisms of Different Proportional Compatibility ofBai-Zhu Fu-Ling Decoction Interfering Spleen-QiDeficiency Crohn's Disease by Intestinal Nerve-immune Network
10.11842/wst.2014.09.038
- VernacularTitle:基于肠“神经-免疫”网络的白术茯苓汤不同配比干预脾气虚型克罗恩病机制研究的探讨
- Author:
Xinglong LIU
;
Bo JIA
;
Hua YAN
;
Jie ZHU
;
Fenghua ZHANG
;
Teng PENG
;
Cen JIANG
;
Wei LIN
;
Shurong MO
;
Xiaohong LI
;
Meiying YUE
;
Qiang ZHONG
- Publication Type:Journal Article
- Keywords:
Bai-Zhu Fu-Ling decoction;
different proportional compatibility;
spleen-qi deficiency Crohn's disease;
nerve-immune network;
mechanism
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(9):2060-2064
- CountryChina
- Language:Chinese
-
Abstract:
s: The onset of Crohn’s disease (CD) is the interaction of environment, heredity, infection, immune and other factors. It is also closely related to abnormal immune functions. Without special treatment, CD is identified as a modern refractory disease. By syndrome differentiation and treatment, traditional Chinese medicine (TCM) can effectively relieve disease conditions, improve the quality of life and reduce side effects of modern medication. The core compatibility ofBai-Zhu andFu-Ling can reinforce spleen-qi and dispel dampness, which met the common pathogenesis of CD. Therefore, the combination is comprehensively used in the compound prescription. Our previous study found thatBai-Zhu Fu-Ling decoctioncan reduce the vasoactive intestinal peptide (VIP) of animal model of spleen-qi deficiency, downregulate VIP receptors, decrease the affinity of VIP receptors and improve animal model’s sIgA. To further clarify the effects about neurotransmitters and their correlation with the immune system in the pathogenesis of CD and the intervention mechanism treated by different proportional compatibility ofBai-Zhu Fu-Ling decoction, we studied influences of the decoction on related transmitters of nerve- immune network and functions of receptors, as well as cytokine secretion and signal transduction of TLR4-NF-κB. Our studies can provide references and foundations to further explore TCM treatment of CD.
