Correlation of transcription factor Sp1 expression with clinical and pathological characteristics and prognosis of hepatocellular carcinoma
10.3969/j.issn.1000-8179.20140694
- VernacularTitle:转录因子Sp1表达与肝癌临床病理特征及预后的关系
- Author:
Qi PAN
;
Kai ZHU
;
Wanyong CHEN
;
Jubo ZHANG
;
Huichuan SUN
;
Lu WANG
;
Ning REN
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
transcription factor Sp1;
prognostic factor;
tissue chip
- From:
Chinese Journal of Clinical Oncology
2014;(20):1284-1287
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the clinical significance of transcription factor Sp1 expression in hepatocellular carcinoma (HCC) and association between Sp1 expression and survival in HCC patients. Methods:With the use of immunoreactivity, Sp1 expres-sion and its correlation with other clinicopathological characteristics were examined in a tissue microarray that contains samples from 98 HCC patients. Results:HCC tissues expressed markedly higher levels of Sp1 than did adjacent normal liver tissues. Sp1 expression was closely associated with microvascular invasion, which suggests that HCC with more microvascular invasion is prone to have in-creased Sp1 expression. Overexpression of Sp1 correlates with significantly shorter overall survival and higher recurrence rates in HCC patients after curative resection. Conclusion:Transcription factor Sp1 may be an independent prognostic factor for both overall surviv-al and cumulative recurrence rate.
