The study on CASP 8-652 6N I/D polymorphism and susceptibility of 2 type diabetes mellitus

VernacularTitle:CASP 8基因-6526N I／D多态性与2型糖尿病易感性的关系
Author: Xuemei HE ; Juan LI ; Xiaoping TANG ; Yongping HE ; Chuanfei HU ; Feng CHEN ; Qin WAN ; Zhuang CHEN
Publication Type:Journal Article
Keywords: Diabetes mellitus,type 2; Cysteine aspartic acid specific protease 8; Polymorphism
From: The Journal of Practical Medicine 2014;(19):3073-3075
CountryChina
Language:Chinese
Abstract: Objective To investigate the association of cysteine aspartic acid specific protease 8 (CASP 8) gene-652 6N Insertion/Deletion polymorphisms and susceptibility of type 2 diabetes mellitus (T2DM). Methods CASP 8 gene -652 6N I/D polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing in 414 controls and 410 patients with T2DM. Results I/I, I/D and D/D genotype frequency were 56.5%, 38.9%, 4.6%in controls and 58.0%, 32.9%, 9.0%in T2DM group respectively (P<0.05). The risk in D/D genotype people was 1.916 times than I/I genotype (adjusted OR=1.916, 95%CI=1.199~3.054, P<0.05). The fasting blood sugar of D/D genotype people was significantly higher than that of I/D and I/I genotype people (P<0.05). Conclusions CASP 8 gene-652 6N I/D polymorphisms are associated with T2DM outbreak.