Significance and detection of Aβ42 and P-tau levels in CSF of patients with mild cognitive impairment

VernacularTitle:轻度认知障碍患者脑脊液中β-淀粉样蛋白42及磷酸化Tau蛋白的水平检测及意义
Author: Lizhu HAN ; Wenjing WANG ; Zhonghai CHU ; Yuanbo WU ; Lei WU ; Zhaozhao CHENG ; Anyuan SUN
Publication Type:Journal Article
Keywords: Cognitive impairment; Aβ42; P-tau; Cerebrospinal fluid
From: The Journal of Practical Medicine 2014;(19):3079-3081
CountryChina
Language:Chinese
Abstract: Objective To investigate Aβ42 and P-tau levels in cerebrospinal fluid (CSF) of patients with mild cognitive impairment (MCI). Methods CSF of 25 cases of MCI and 14 cases of cognitively normal (CN) were investigated. The CSF levels of Aβ42 and P-tau were detected by ELISA method. Correlation analysis was used to analyze the correlation between P-tau level and MMSE score in MCI. Results The CSF level of Aβ 42 was higher and P-tau was lower in MCI than CN group(P<0.05). P-tau level in MCI was also negatively correlated with MMSE score (P<0.05). Conclusion Aβ42 and P-tau levels in CSF may be valuable biological markers in the diagnosis of MCI. P-tau level in CSF of MCI may be related to the severity of cognitive impairment.