Expression and significance of insulin like growth factor-Ⅱ mRNA binding protein3 (IMP3) in gastrointestinal stromal tumors
10.3969/j.issn.1006-5725.2014.19.020
- VernacularTitle:胃肠道间质瘤中IMP3的表达及意义
- Author:
Zhuxue ZHANG
;
Yingchun YANG
;
Wei YI
;
Anzhi WEN
;
Qian WU
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumor;
IMP3;
Ki67;
Immunihistochemistry
- From:
The Journal of Practical Medicine
2014;(19):3092-3095
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of Insulin like growth factor-ⅡmRNA binding protein3 (IMP3) in gastrointestinal stromal tumors (GIST). Methods One hundred and fifteen cases of GIST were subjected to immunohistochemical staining for IMP3 (SP method) and ki67 (iVisionTM method ). The relationship between IMP3 expression with clinicopathologic parameters and Ki67 proliferation indexes were analyzed. In situ hybridization detection of IMP3 mRNA was performed in 20 cases of GIST positive. Results The expression rate of IMP3 was 56.2%(65/115) in GIST positive. A significant correlation can be found between IMP3 expression and tumor of infiltration , coagulative necrosis , metastasis , nuclear atypia , diameter , mitotic count , risk grade of NIH (P < 0.05), while there was no significant correlation between IMP3 and gender, age, primary location, categories of cell type (P>0.05). There was positive correlation of IMP3 expression and Ki67 labeling indexes by Spearman analysis. Positive expression with IMP3 can be observed in 3 cases of recurrence.It may play important role in invasive and development and may be an important factor of prognosis in GIST.
