A primary study of the relationship between apparent diffusion coefficient value of rectal adenocarcinoma on DWI and its pathological grading

VernacularTitle:直肠腺癌 MRI 表观扩散系数值与分化程度相关性的初步研究
Author: Jin ZHU ; Zhiqiang CHENG ; Mingli YANG ; Wenyan KANG ; Jingshan GONG ; Ligang XIA ; Jianmin XU
Publication Type:Journal Article
Keywords: rectal adenocarcinoma; magnetic resonance imaging; apparent diffusion coefficient; grading
From: Journal of Practical Radiology 2015;(6):938-941
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between apparent diffusion coefficient (ADC)value of rectal adenocarcinoma on DWI and its pathological grading.Methods The ADC values of 46 rectal adenocarcinomas were measured and compared with their histopathological grades.Results The 46 rectal adenocarcinomas included well differentiated adenocarcinomas in 14,moderate-ly differentiated ones in 20,and poorly differentiated ones in 12.The ADC values of well,moderately and poorly differentiated ade-nocarcinomas were (1.125±0.103)×10 -3 mm2/s,(1.030±0.098)×10 -3 mm2/s and (0.922±0.091)×10 -3 mm2/s,respective-ly,exhibiting a statistical difference (χ2 =1 7.35 1,P =0.000).Mann-Whitney U test showed that difference in ADC value between different histopathological grades was statistically significant.Conclusion ADC value of rectal adenocarcinoma can be used as a bio-marker for cell grading to guide treatment decision and prognosis assessment.