Correlation Between Aldosterone and Gestational Diabetes Mellitus
10.3969/j.issn.0253-9896.2014.11.011
- VernacularTitle:醛固酮与妊娠糖尿病的相关性研究
- Author:
Liping LI
;
Jie LIU
;
Yujin MA
- Publication Type:Journal Article
- Keywords:
diabetes,gestational;
aldosterone;
regression analysis;
insulin resistance
- From:
Tianjin Medical Journal
2014;(11):1094-1096
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between plasma aldosterone level and gestational diabetes melli?tus. Methods All subjects were divided into three groups (n=20 in each group):gestational diabetes mellitus (GDM) group, pregnancy with normal glucose group,non-pregnant healthy women group. Pre-pregnant body mass index (BMI) was calcu?lated, and fasting blood glucose (FBG), blood lipid level, Fins, HOMA-IR index, RASS, PRA, ATIi and ALD were examined besides glucose intolerance test. Results The plasma ALD level was significantly higher in GDM group than that of NGT group and control group(pmol/L:1 130.15±135.45 vs 1 053.98±108.86 vs 544.31±127.97). The plasma ALD level was posi?tively correlated with FBG,1 h PBG ,2 hPBG,Fins , HOMA-IR and blood triglyceride (r=0.657, 0.757, 0.713, 0.429,P<0.05),but negatively correlated with HDL-C(r=-0.267,P=0.039). Stepwise regression analysis revealed that plasma aldo?sterone was the independent risk factor of GDM. Conclusion RASS is excessively activated in pregnancy, which contrib?utes to gestational diabetes mellitus.