Study on Analgesic and Antipyretics Effect of Re-Du-Ning Injection
10.11842/wst.2014.09.009
- VernacularTitle:热毒宁注射液解热镇痛作用研究
- Author:
Jian CHEN
;
Xiujuan CHANG
;
Chunmiao CHEN
;
Yaozhong LYU
;
Jun ZHOU
;
Zhenzhong WANG
;
Wei XIAO
- Publication Type:Journal Article
- Keywords:
Re-Du-Ning Injection;
analgesic;
antipyretics;
experimental research
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(9):1912-1915
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study the analgesic and antipyretic effect of Re-Du-Ning (RDN) Injection. Heating model was building on SD rats after subcutaneous injection of yeast. And then, RDN Injection was intravenous injected at the dose of 10.16 g·kg-1, 5.08 g·kg-1, and 2.54 g·kg-1, respectively. Observation was made on changes of rats' temperature. RDN Injection was intravenous injected into ICR mice at the dose of 20.30 g·kg-1, 10.15 g·kg-1, 5.08 g·kg-1 for 7 consecutive days. The methods of mice twist, hot plate and jaw pain were used in the testing of analgesic action of RDN Injection. The results showed that RDN Injection at high and middle dose can significantly reduce the temperature of heating rats models (P < 0.05 or P < 0.01). It can also significantly reduce the twisting times of mice by acetic acid (P< 0.05 or P< 0.01). It can also significantly increase the pain threshold of mice by hot plate and jaw pain (P< 0.05 or P< 0.01). It was concluded that RDN Injection had a good analgesic and antipyretic effect in mice.