Effects of Different Constitutional Types of Coronary Heart Disease with Blood Stasis Syndrome among Patients with ApoE Gene Polymorphism on Vascular Endothelial Cell Function
10.11842/wst.2014.09.029
- VernacularTitle:不同体质类型CHD心血瘀阻证患者ApoE基因多态性对血管内皮细胞功能的影响
- Author:
Song TIAN
;
Ruoke QI
;
Xiaoxue WU
;
Qian HE
;
Yuezhao CHENG
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
heart blood stasis syndrome;
gene polymorphism;
constitution;
endothelial cell function
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(9):2020-2024
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study the distribution and effects of apolipoprotein E (ApoE) gene polymorphism of different constitutional types among coronary heart disease (CHD) patients with blood stasis syndrome on vascular endothelial cell (VEC) function. The whole gene sequencing method was used to identify genotypes of ApoE gene among 556 CHD patients with blood stasis syndrome, in order to analyze the relationship between polymorphism of ApoE gene and the level of VEC function. The results showed that the frequency of E3/3 genotype of each physical group was significantly lower than that of the healthy group; and the frequency of E3/4 genotype was significantly higher than that of the healthy group. In addition, the frequency of E3/3 genotype in qi deficiency constitution group was higher than that of blood stasis constitution group and yang deficiency constitution group; but the frequency of E3/4 genotype in blood stasis constitution group and yang deficiency constitution group was higher than that of the qi deficiency constitution group. The levels of ET and ET/NO in each of genotype groups of blood stasis constitution, yang deficiency constitution, qi deficiency constitution of CHD patients with blood stasis syndrome were higher than that of the healthy group (P < 0.05). In the genotype group of blood stasis constitution of CHD patients with blood stasis syndrome, the frequency of E3/4+E4/4 genotype ET was higher than that of other genotypes (P < 0.01). The levels of ET, NO, ET/NO in genotype groups of yang deficiency constitution and qi deficiency constitution of CHD patients with blood stasis syndrome were not significantly different. It was concluded that ApoE genotype E3/4, E3/3 may be the susceptible genotypes of blood stasis syndrome in CHD. There is a certain difference among different constitutional types. CHD with blood stasis syndrome patients, who are the constitution of blood stasis, carrying the ApoE gene polymorphism of E4 allele may have the function of increasing the ET level.
