Malignant transformation in monostotic fibrous dysplasia:clinical and imaging features

VernacularTitle:单骨型纤维结构不良肉瘤变的临床特征及影像诊断
Author: Nan QU ; Weiwu YAO
Publication Type:Journal Article
Keywords: fibrous dysplasia; sarcomatous change; computed tomography; magnetic resonance imaging
From: Journal of Practical Radiology 2015;(6):969-973
CountryChina
Language:Chinese
Abstract: Objective To investigate clinical and imaging features of malignant transformation in monostotic fibrous dysplasia (FD).Methods Radiography (n=12),computed tomography (CT)(n=7)and magnetic resonance imaging (MRI)(n=5)data of 12 monostotic FD cases proved by surgery and pathology were retrospectively reviewed.Results Among 12 cases,6 cases underwent surgery.Their images showed osteolytic lesions in the operative area with direct signs of aggressiveness (poorly defined margin,cor-tical destruction and soft tissue mass).For the 6 cases without surgery,radiography and CT showed poorly margin,osteolytic le-sions within or near the area of ground-glass opacity.MRI showed lesions with heterogeneous signal intensity and pronounced con-trast-enhancement.Histopathologically,9 cases were osteosarcomas,2 cases were fibrosarcomas,and 1 case was malignant fibrous histiocytoma (MFH).Conclusion The imaging information of malignant transformation of FD can provide evidence of possible ma-lignancy.