Correlation between abnormal heterogeneous nuclear ribonucleo-protein expression and tumors
10.3969/j.issn.1000-8179.20141459
- VernacularTitle:核不均一性核糖核蛋白的异常表达与肿瘤发生
- Author:
Rong GUO
;
Yong LI
- Publication Type:Journal Article
- Keywords:
hnRNP A1 gene;
hnRNP A2 gene;
tumor;
alternative splicing
- From:
Chinese Journal of Clinical Oncology
2014;(22):1466-1469
- CountryChina
- Language:Chinese
-
Abstract:
Heterogeneous nuclear ribonucleoprotein (hnRNP) is a family of multifunctional nuclear RNA-binding proteins that regulate the alternative splicing of pre-mRNA and the transport, translation, and stability of mRNA. The most abundant and best charac-terized proteins of this group are hnRNP A1 and hnRNP A2, which share a high degree of sequence homology and functional similarity. HnRNP A1 and hnRNP A2 are upregulated in multiple human tumors and modulate the alternative splicing and mRNA stability of vari-ous tumor-related genes critical to tumor cell growth, apoptosis, inflammatory and immune reactions, and epithelial-to-mesenchymal transition. Therefore, hnRNP A1 and hnRNP A2 have potential diagnostic, prognostic, and therapeutic values.
