Expression of 4-1BB and lymphocyte subsets in peripheral blood of children with acute infectious lymphocytosis

VernacularTitle:急性传染性淋巴细胞增多症患儿外周血共刺激分子4-1BB和淋巴细胞亚群的表达及意义
Author: Qiang FU ; Qihua FENG ; Konggui YU ; Linfei TANG ; Aimin LI ; Xiaoxiang SONG
Publication Type:Journal Article
Keywords: lymphocyte subset; acute infectious lymphocytosis; lfow cytometry; child
From: Journal of Clinical Pediatrics 2014;(10):928-930
CountryChina
Language:Chinese
Abstract: Objective To investigate expression of 4-1BB and lymphocyte subsets in peripheral blood of children with acute infectious lymphocytosis. Methods Flow cytometry (FCM) was applied to detect the expression of 4-1BB and lymphocyte subsets in peripheral blood of 15 cases of acute infectious lymphocytosis and 20 cases of acute upper respiratory infection, and 20 healthy children. Results The expression of 4-1BB and CD3+, CD4+and CD8+lymphocytes were higher in acute infectious lymphocytosis group than those in acute upper respiratory infection group and healthy control group (P<0.05). There was no sig-niifcant difference of CD19+CD23+lymphocytes among three groups (P>0.05). A positive correlation was found between 4-1BB expression and CD3+ lymphocytes expression in acute infectious lymphocytosis group (r=0.73, P<0.05). Conclusions The abnormal expression of 4-1BB may play a pathological role in the development of acute infectious lymphocytosis. T cells in chil-dren with acute infectious lymphocytosis may not function to activate B cells.