Establishment and evaluation of a whole-body dynamic inhalation exposure system
10.7644/j.issn.1674-9960.2014.10.008
- VernacularTitle:全身暴露动态吸入染毒系统的建立与评价
- Author:
Zhiyong NIE
;
Xin SUI
;
Xiaohong SUN
;
Xiaoping WANG
;
Yongan WANG
- Publication Type:Journal Article
- Keywords:
inhalation exposure;
exposure chamber;
aerosol
- From:Military Medical Sciences
2014;(10):780-783
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a whole-body dynamic inhalation exposure system for toxicological studies on highly toxic chemicals, and to evaluate the safety and applicability of the system.Methods The safety and standardization of the laboratory were ensured after positive and negative pressure protection and airtight protection were finished.By modifying and optimizing the key technological units of the exposure chamber, the relationships between aerosol concentrations in the chamber and the push rate, exposure time and different monitoring points were investigated.Results and Conclusion Multi-protection was achieved, including the independent exposure chamber, negative pressure experiment and positive pressure protection under working conditions.The laboratory meets the demands of safety and specifications.The exposure aerosol concentrations in the chamber are uniform, stable and controllable while the air is dynamically flowing.The whole-body dynamic inhalation exposure system can meet the need for toxicological studies on highly toxic chemicals.
