Effects of 1,25-dihydroxyvitamin D3 on the expression of urinary nephrin in diabetic nephropathy patients

VernacularTitle:1，25-二羟维生素D3对糖尿病肾病患者尿足细胞相关蛋白Nephrin的影响
Author: Li LI ; Song LU ; Hua GAN
Publication Type:Journal Article
Keywords: diabetic nephropathy; calcitriol; podocyte; Nephrin
From: Chongqing Medicine 2014;(30):4002-4004
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of 1 ,25-dihydroxyvitamin D3 on the expression of urinary Nephrin in patients with diabetic nephropathy .Methods According to albumin excretion rate ,40 type-2 diabetic nephropathy patients were divided into 2 groups ,10 healthy volunteers served as control .The treatment groups received 1 ,25-dihydroxyvitamin D3 0 .25 μg/d for 12 weeks .The levels of blood calcium ,phosphorus ,serum creatinine ,24-hour urinary protein excretion were detected .Enzyme-linked immunosorbent assay was used to detect urinary Nephrin in different groups .Results The expressions of urinary Nephrin were sta-tistically different among NC group ,DN1 group and DN2 group .1 ,25-dihydroxyvitamin D3 treatment significantly decreased the ex-pression of urinary Nephrin in DN1 patients ,whereas no statistically changes were observed in DN2 group .Conclusion In diabetic nephropathy patients ,urinary Nephrin is supposed to be effective an marker of disease progression .1 ,25-dihydroxyvitamin D3 may be effective to prevent podocyte injury in early-stage diabetic nephropathy .