Effect of Trimetazidine on T-peak to T-end Interval in Patients With Unstable Angina Pectoris After Percutaneous Coronary Intervention
10.3969/j.issn.1000-3614.2014.10.005
- VernacularTitle:曲美他嗪对不稳定性心绞痛患者经皮冠状动脉介入治疗术后心电图Tp-Te间期的影响
- Author:
Shuhan YANG
;
Jinsong CHENG
;
Yanbin LIU
;
Minglei HAN
;
Cheng WANG
- Publication Type:Journal Article
- Keywords:
Percutaneous coronary intervention;
Cardiac troponin I;
Trimetazidine;
Unstable angina pectoris;
T-peak to T-end interval
- From:
Chinese Circulation Journal
2014;(10):776-779
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of trimetazidine (TMZ) on T-peak (Tp) to T-end (Te) interval of resting ECG in patients with unstable angina pectoris (UAP) after percutaneous coronary intervention (PCI). Methods: We investigated 94 UAP patients with PCI and 76 of them ifnished the study as 2 groups. Control group,n=42, the patients received conventional treatment, and TMZ group,n=34, in addition to conventional treatment, the patients received TMZ 60 mg at 0.5 to 1 hour before PCI. The changes of Tp to Te interval before and after PCI were calculated, serum levels of creatine kinase (CK), creatine kinase-MB (CK-MB) and cardiac troponin I (cTnI) at before and at 6, 24 hours after PCI were compared between 2 groups. Ventricular arrhythmia was recorded during PCI. Results: Both groups had shortened Tp to Te intervals after PCI, and TMZ group had more shortened Tp to Te interval, bothP<0.05, while the Tp to Te intervals were similar between 2 group before PCI,P>0.05. The occurrence rate of ventricular arrhythmia in Control group was higher than that in TMZ group (12.52% vs 5.16%) during PCI,P<0.05. Compared with Control group, TMZ group had lower levels of CK, CK-MB and cTnI at 6, 24 hours after PCI, allP<0.05. Conclusion: TMZ could decrease Tp to Te interval of resting ECG, prevent ventricular arrhythmia and reduce the relevant myocardial injury in UAP patients after PCI.
