Advances in assay of EML4-ALK gene rearrangements in non-small-cell lung cancer
10.7644/j.issn.1674-9960.2014.09.021
- VernacularTitle:非小细胞肺癌EML4-ALK融合基因检测技术研究进展
- Author:
Jian CHEN
;
Zhihua LI
;
Xiaoqing LIU
- Publication Type:Journal Article
- Keywords:
non-small-cell lung cancer;
EML4-ALK;
proteomics
- From:Military Medical Sciences
2014;(9):741-744
- CountryChina
- Language:Chinese
-
Abstract:
Echinoderm microtubule associated protein like 4-anaplastic lymphomakinase ( EML4-ALK) rearrangement is another driver-mutation in non-small-cell lung cancer (NSCLC) besides epidermal growth factor receptor (EGFR).Accu-rate identification of EML 4-ALK lung adenocarcinoma is essential for the selection of appropriate therapy .Immunohisto-chemistry (IHC), fluorescence in situ hybridization (FISH), and polymerase chain reaction (PCR) are the main three assay methods for clinical practice .Recently, researchers have done lots of work on the exploration of detection , diagnosis, and treatment prediction of carcinoma based on serum proteomics .In this paper, recent developments in these fields are reviewed.
