Research progress on the regulatory mechanisms of mammalian blastocyst hatching
10.7644/j.issn.1674-9960.2014.09.022
- VernacularTitle:哺乳动物囊胚孵化调控机制的研究进展
- Author:
Xiyan WANG
;
Xiaoyan PAN
;
Zhixin LI
;
Xuenan WANG
- Publication Type:Journal Article
- Keywords:
blastocyst hatching;
trophectodermal projections;
implantation;
regulatory mechanism;
assisted hatching
- From:
Military Medical Sciences
2014;(9):745-747
- CountryChina
- Language:Chinese
-
Abstract:
Prior to implantation, the blastocyst has to hatch out of its zona pellucida to invade the endometrium .In mammals including humans , failure of blastocyst hatching leads to infertility .Blastocyst hatching is believed to be regulated by a variety of autocrine and paracrine molecules such as proteases , cyclooxygenase-2, p38 mitogen-activated protein ki-nase, activin A and Wnt signal pathway .This article reviews the mechanisms of the key molecular regulators involved in mammalian blastocyst hatching and hatching-assisting methods , which can help clarify the mechanism of blastocyst hatching and the treatment of infertility due to failure in blastocyst hatching .
