Correlation Between Shear Wave Elasticity and Collagen Fiber in Breast Disease
10.3969/j.issn.1005-5185.2014.10.001
- VernacularTitle:乳腺病变剪切波弹性模量与胶原纤维的相关性
- Author:
Zhili WANG
;
Lu SUN
;
Yazhuo HU
;
Ye LI
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Ultrasonography,mammary;
Elasticity imaging techniques;
Collagen;
Pathology,surgical
- From:
Chinese Journal of Medical Imaging
2014;(10):721-724
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the differences of shear wave elasticity and the content of collagen fiber between benign breast lesions and malignant breast lesions, and to analyze the correlation between shear wave elasticity and the content of collagen fiber. Materials and Methods 106 patients with 116 breast lesions who were referred to PLA General Hospital for ultrasound-guided biopsy or surgery underwent shear wave elasticity examination, the biopsy specimen underwent Van Gieson (VG) dye and Image-Pro Plus 5.1 software was used to quantitatively analyze the content of collagen fiber. Results Malignant lesions exhibited signiifcantly higher max elasticity, mean elasticity, and elasticity ratio between lesions and surrounding parenchyma (140.43±70.16) kPa, (63.11±33.68) kPa, 3.49±1.95 than benign lesions (54.64±48.53) kPa, (34.52±25.23) kPa, 2.25±1.48 (t=5.329, 4.382 and 4.487, P<0.01). The content of collagen fiber of malignant lesions was signiifcantly higher than that of benign lesions (t=8.437, P<0.01). There was a positive correlation between max elasticity and the content of ifber collagen (r=0.746, P<0.05). Conclusion The elasticity of breast lesions has a close correlation with the content of collagen ifber, and collagen ifber might play an important role in the development of breast carcinoma.
