Change of Human Cerebral Glucose Metabolism with Age and Gender by Using Scenium Software
10.3969/j.issn.1005-5185.2014.09.005
- VernacularTitle:Scenium软件研究不同性别正常人脑葡萄糖代谢随年龄变化的规律
- Author:
Mei XU
;
Rong NIU
;
Xiaonan SHAO
;
Xiaoliang SHAO
;
Xiaosong WANG
;
Yuetao WANG
- Publication Type:Journal Article
- Keywords:
Positron emission tomography;
Tomography,X-ray computed;
Brain;
Glucose;
Metabolism;
Sex factors;
Adult
- From:
Chinese Journal of Medical Imaging
2014;(9):659-663
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To analyze the PET image of normal human brain by using Scenium software, so as to ifnd out the change of cerebral glucose metabolism with different age and gender. Materials and Methods Brain PET imaging data of 493 healthy males and 273 healthy females were collected in the study. The subjects were divided into 6 groups according to age:21-30 years group,31-40 years group, 41-50 years group, 51-60 years group, 61-70 years group and 71-82 years group. Each group was further subdivided according to gender. The brain areas were automatically outlined by Scenium and the mean standard uptake value (SUV) of each brain area was calculated and compared among groups. Results Most cerebral glucose metabolism of males at different age was significantly different (F=2.580-5.316, P<0.05), except temporal lobe in right side and cerebellum showed no difference (F=1.611-1.935, P>0.05); whilst difference in cerebral glucose metabolism of females at different age was not signiifcant (F=0.721-1.706, P>0.05). In male groups, cerebral glucose metabolism got peak at 31-40 years, and decreased signiifcantly at 51-60 years mainly involving areas like cinglulate gyrus, calcarine and surrounding cortex;and the groups after 61 years showed no signiifcant decrease. In female groups, cerebral glucose metabolism got peak at 31-40 years and showed no significant decrease along with age. Conclusion Cerebral glucose metabolism decreases unevenly after 40 years old. It drops significantly in males at 51-60 years whilst that in females is not obvious.
