The Effects and Mechanism of Lidocaine on Evoked-Bursting Firing of Injured Dorsal Root Ganglion Neurons

VernacularTitle:利多卡因对背根节神经元诱发簇放电的影响及机制
Author: Tao SUN ; Ying SONG ; Zhen LEI
Publication Type:Journal Article
Keywords: neurons; lidocaine; dorsal root ganglion neuron; evoked-bursting; sodium current
From: Tianjin Medical Journal 2014;(11):1073-1075
CountryChina
Language:Chinese
Abstract: Objective To study the effects and current mechanism of low concentration of lidocaine on evoked-bursting (EB) firing of dorsal root ganglion (DRG) neurons in rat model of chronic compression (CCD) of DRG . Methods Twenty-four SD rats were divided into normal control group (n=12) and CCD model group (n=12). CCD group was treated with chronic oppression on L4 and L5 DRG with L shape bar. Normal control group received no treatment. In vivo intracellu?lar recording was used to record the incidence of EB and the effect of lidocaine on subthreshold membrane potential oscilla?tion (SMPO). Patch clamp recording was used to record the effect of lidocaine on persistent sodium current (INaP). Results The incidence of EB increased in CCD group( 45.97%, 57/124), which was significantly different when compared with nor?mal group (χ2=26.810, P<0.01). The magnitude of SMPO, INaP and EB were inhibited in a reversible way by lidocaine (50μmol/L). Conclusion The low concentration of lidocaine might play an analgesic effect in peripheral nervous system by se?lectively inhibiting INap, which participates in SMPO formation.