The Research Progress of Tumor Necrosis Factor Alpha in Multiple Sclerosis and Remyelination
10.3969/j.issn.0253-9896.2014.11.027
- VernacularTitle:肿瘤坏死因子α在多发性硬化及髓鞘再生中的研究进展
- Author:
Xudan LEI
;
Fei XU
;
Yuhao LI
- Publication Type:Journal Article
- Keywords:
tumor necrosis factor-alpha;
receptors,tumor necrosis factor;
multiple sclerosis;
myelin sheath;
remye-lination;
review
- From:
Tianjin Medical Journal
2014;(11):1141-1143
- CountryChina
- Language:Chinese
-
Abstract:
Tumor necrosis factor (TNF)-αis a pleiotropic inflammatory cytokine, which is produced chiefly by acti?vated macrophages. Two forms of TNF-α, soluble and transmembrane, can bind tumor necrosis factor receptor (TNFR) 1 or TNFR2, respectively. Recently, a concept has emerged that TNF-α/TNFR pathway plays an important role in the pathogene?sis of multiple sclerosis and remyelination. TNFR1 induces death of oligodendrocytes via death receptor-mediated apoptosis, which leads to demyelination or other neurodegenerative changes. However, TNFR2 has a positive effect on multiple sclero?sis. It facilitates the proliferation and differentiation of oligodendrocyte precursor cells, thus promoting remyelination.
