Oncogenic mutation profiles involved in melanoma in Southern China
10.3969/j.issn.1000-8179.20132055
- VernacularTitle:华南地区黑色素瘤癌基因突变谱分析
- Author:
Qiming ZHOU
;
Xing ZHANG
;
Ya DING
;
Ruiqing PENG
;
Shumei YAN
;
Xiaoshi ZHANG
- Publication Type:Journal Article
- Keywords:
melanoma;
oncogene;
mutation
- From:
Chinese Journal of Clinical Oncology
2014;(21):1343-1347
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the oncogenic mutations involved in melanoma in Southern China and to provide a theoretical basis for the development of melanoma molecular targeted therapy strategy. Methods:The Sequenom platform (OncoCarta Panel v1.0 and MassARRAY System) was used to determine the prevalence of oncogene mutations in 28 acral melanoma samples, 28 mucosal mel-anoma samples, and 30 non-chronic sun-induced-damage (no-CSD) melanoma samples from Southern China. Results:At least one mu-tation was detected in 33 of the 86 melanomas (38.4%) with mutations observed in BRAF (16.3%), NRAS (10.5%), KIT (5.8%), EGFR (4.7%), HRAS (2.3%), KRAS (2.3%), MET (2.3%), and PIK3CA (1.2%). In BRAF, the age of patients with mutations was significantly lower than those without BRAF mutation (45.7±15.3 vs. 55.9±12.7, P=0.01). Patients with mutations in NRAS were more likely to have ulceration compared with patients without NRAS mutations (88.9%vs. 48.1%, P=0.049). Conclusions:This study represents a compre-hensive and concurrent analysis of the major recurrent oncogenic mutations involved in melanoma cases from Southern China areas. The data have implications for both clinical trial designs and therapeutic strategies.
