Research on effect of esomeprazole in treating elderly patients with NSAIDs correlated peptic ulcer bleeding
10.3969/J.ISSN.1672-8270.2014.10.047
- VernacularTitle:埃索美拉唑治疗老年人非甾体抗炎药相关性消化性溃疡出血的临床疗效探讨
- Author:
Lei WANG
;
Qian WANG
- Publication Type:Journal Article
- Keywords:
Peptic ulcer;
Non steroidal anti-inflammatory drugs;
Esomeprazole;
Ulcer bleeding
- From:
China Medical Equipment
2014;(10):131-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of esomeprazole in treating elderly patients with NSAIDs correlated peptic ulcer bleeding. Methods: Patients with NSAIDs correlated peptic ulcer bleeding in our hospital from January, 2010-December, 2012 were enrolled and randomly divided into observation group given esomeprazole and control group given omeprazole. Then the baseline data were surveyed and effect of ulcer bleeding, condition of abdominal pain alleviation and ulcer ulcer, adverse reaction cases were observed. Results: (1)there were no significant difference between the baseline data of two group;(P>0.05);(2)in observation group, excellence rate was 42/70(60%), effective rate was 24/70(34.3%), the overall treatment effect was better than that of control group, the difference had statistical significant(P<0.05);(3)there were no significant difference between two group of abdominal pain and ulcer healing;(4) during treatment, there were no serious adverse reactions in the two groups. Conclusion:Compared with omeprazole, esomeprazole has equal effect on abdominal pain relief and ulcer healing, and it is much more effective in treating elderly patients with NSAIDs correlated peptic ulcer bleeding.
