Analysis of the curative effect and survival of postoperative adjuvant chemotherapy for stage Ⅱ/Ⅲ colon cancer
10.3760/cma.j.issn.1008-6706.2014.21.026
- VernacularTitle:Ⅱ／Ⅲ期结肠癌术后辅助化疗疗效与生存分析
- Author:
Runhua LI
- Publication Type:Journal Article
- Keywords:
Colonic Neoplasms;
Antineoplastic Combined Chemotherapy Protocols
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(21):3267-3269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy of stageⅡ/Ⅲcolon cancer postoperative adjuvant chemotherapy and survival time.Methods 108 stage Ⅱ/Ⅲ colon cancer patients with postoperative adjuvant chemotherapy were selected as the study group,and in the same period 52 stage Ⅱ/Ⅲ colon cancer patients with only simple surgery treatment were selected as the control group.The adjuvant curative effect of the two groups were analyzed and the sur-vival time was followed up.Results The patients of the two groups were followed up for 3 years.The median disease-free survival time of the study group was 18 months,disease-free survival rate was 69.44%,26 cases in recurrence and transfer,accounted for 24.07%,and 7 cases(6.48%) died;The median disease-free survival time of the control group was 12 months and the disease-free survival rate was 46.15%,18 cases in recurrence and transfer, accounted for 34.62%,and 10 cases(19.23%) died.The median disease-free survival,recurrence and transfer rate of the control group were statistically significant better than those of the control group(χ2 =8.07,4.74,all P<0.05).Postoperative adjuvant chemotherapy in patients with adverse reaction was mainly for nausea and vomiting,loss of appetite,pigmentation and hair loss up to see, but were comparatively light, and very little serious most patients could be tolerated.Conclusion The postoperative adjuvant chemotherapy for patients with stageⅡ/Ⅲcolon cancer can reduce postoperative recurrence,metastasis,improve patients'survival time,prolong patient life.
