Intestinal microflora changes in children with Henoch-Sch?nlein purpura

VernacularTitle:过敏性紫癜患儿肠道菌群的变化
Author: Wen LUO ; Hua XU ; Xiaoqing CHEN ; Huasong ZENG ; Zhuoyin LIN
Publication Type:Journal Article
Keywords: Henoch-Sch?nlein purpura; intestinal lfora; child
From: Journal of Clinical Pediatrics 2014;(10):907-911
CountryChina
Language:Chinese
Abstract: Objective To study the intestinal microflora changes in children with Henoch-Sch?nlein purpura (HSP). Methods The feces of 64 children with HSP (the experimental group) and 25 healthy children (the control group) were collected. 16S rRNA/DNA fluorescent quantitative polymerase chain reaction were performed to detect bacterial content of Lactobacillus, Biifdobacterium and Escherichia coli in feces. Results The amounts of Lactobacillus, and Biifdobacterium in the HSP group were lower than those of the healthy group, and the amounts of E.coli were higher, but the differences were not statistically signiifcant. The amounts of Lactobacillus and Biifdobacterium in the HSP children with gastrointestinal symptoms (abdominal pain, vomiting, e.g.) were signiifcantly lower than those in HSP children without gastrointestinal symptoms and in the healthy group. The difference was signiifcant (P<0.05). Conclusions It suggests that intestinal microlfora in children with HSP in acute phase may exist disorders, especially in the HSP children with gastrointestinal symptoms.