The role of urinary kidney injury molecule-1 in pediatric Henoch-Sch?nlein purpura

VernacularTitle:过敏性紫癜患儿尿肾脏损伤因子-1水平的变化及意义
Author: Hui XIA ; Youying MAO ; Wei ZHOU ; Tongxin CHEN
Publication Type:Journal Article
Keywords: Henoch-Sch?nlein purpura; kidney injury molecule-1; child
From: Journal of Clinical Pediatrics 2014;(10):918-920
CountryChina
Language:Chinese
Abstract: Objective To study the role of urinary kidney injury molecule-1 (KIM-1) in pediatric Henoch-Sch?nlein purpura (HSP). Methods Urinary levels of KIM-1 were examined using ELISA in 48 children with HSP including 23 HSPN children (HSPN group) and 25 non-HSPN children (HSP group), and 20 healthy children. The levels of urinary creatinine and 24-hour urine protein were also detected. The results were analyzed and compared among groups. Results The ratio of urinary KIM-1/creatinine (Cr) in HSPN children was signiifcantly higher than that in the other two groups (P<0.05). There was no signiifcant difference in the ratio of urinary KIM-1/Cr between HSP group and the control group (P>0.05). The ratio of urinary KIM-1/Cr had no correlation with 24-hour urine protein in all HSP children (r=0.239, P=0.590). Conclusions Urinary KIM-1 may play a role in the pathogenesis of pediatric HSPN.