Distribution of Th17 cells in peripheral blood of children with Henoch-Sch?nlein purpura and its clinical significance

VernacularTitle:Th17细胞在过敏性紫癜患儿外周血中的分布及意义
Author: Yanling LI ; Yongqing WANG ; Diqing ZHU ; Yiping ZHOU
Publication Type:Journal Article
Keywords: Henoch-Sch?nlein purpura; T helper lymphocytes 17; interleukin-17
From: Journal of Clinical Pediatrics 2014;(10):921-923
CountryChina
Language:Chinese
Abstract: Objective To observe the percentage of Th17 cells in peripheral blood mononuclear cells (PBMCs) and the serum level of interleukin-17 (IL-17) in children with Henoch-Sch?nlein purpura (HSP). Methods A total of 30 HSP children and 20 healthy children were selected. The percentage of Th17 cells in PBMCs was measured by lfow cytometry analysis and the serum level of IL-17 was measured by ELISA method. The results were compared between HSP children and healthy children. Results The percentage of Th17 cells in PBMCs in HSP and healthy children was (2.14 ± 0.90)%and (0.84 ± 0.41)%, respec-tively, and the difference was signiifcant between two groups (P<0.05). The serum levels of IL-17 in HSP and healthy children were (38.36 ± 13.44) pg/ml and (10.59 ± 4.17) pg/ml, respectively, and the difference was also signiifcant (P<0.05). Conclusions The percentage of Th17 cells in PBMCs was obviously increased in HSP children. It is suggested that Th17 cells may play a role in the pathology of HSP.