Analysis of the change and the influence factors of the immune function of the neonates with hypoxic ischemic encephalopathy
10.3760/cma.j.issn.1008-6706.2014.22.040
- VernacularTitle:缺血缺氧性脑病新生儿免疫功能的变化及影响因素的分析
- Author:
Haihong CAO
- Publication Type:Journal Article
- Keywords:
Hypoxic-Tschemic,brain;
Immune function;
Infant,newbron
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(22):3458-3460
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and analyze the change and the influence factors of the immune function of the neonates with hypoxic ischemic encephalopathy ( HIE) .Methods 60 patients with HIE were selected as the observation group,and 60 healthy neonates were selected as the control group.The CD1+9 ,CD1+9 CD2+5 B lymphocyte per-centages,IgG,IgM,IgA,complement C3,C4 levels in peripheral blood of the neonates in the two groups were detected and analyzed.At the same time, the Apgar scores, placenta condition, amniotic fluid contamination degrees,the modes of delivery,modes of feeding of the neonates in the two groups were observed and compared.Results The percentages of CD1+9 lymphocytes or CD1+9 CD2+5 lymphocytes,IgM,IgA,C3,C4 levels of the neonates in the control group were significantly higher than those of the observation group ( t=3.586,4.158,3.262,3.457,3.056,5.163, all P<0.05);the percentages of CD1+9 lymphocytes or CD1+9 CD2+5 lymphocytes,IgM,IgA,C3,C4 levels of the severe HIE patients were significantly lower than those of the moderate HIE patients or the mild HIE patients ( t=3.285, 4.752,5.113,3.748,4.287,3.953,4.116,5.201,6.284,3.416,5.314,3.928,4.063,6.026,all P<0.05) and the IgA and C4 levels of the moderate HIE patients were significantly lower than that of the mild HIE patients ( t=3.452,3.281,all P<0.05);the percentage of CD1+9 ,IgA,C4 levels of the neonates with HIE were positively cor-related with Apgar score ( r=0.768,0.026,0.016,all P<0.05) .When the choking symptoms were severer,the im-mune indexes decreased more significantly;the IgG,IgM levels of the neonates with HIE were negatively correlated with the amniotic fluid contamination degrees(r=-0732,-0.025,all P<0.05);the IgA level was positively corre-lated with breastfeeding(r=0.053,P<0.05),and the IgG level was positively correlated with the birth weight(r=0.018,P<0.05).Conclusion The immune function of neonates with HIE significantly decreases and the decline of the immune function may be related with the degree of the disease.The birth condition of the neonates,asphyxia,am-niotic fluid contamination degrees,birth weight,feeding mode are the factors affecting the immune function of the pa-tients.
