Polymorphisms of MTHFR and MTRR among the Han women in Laiwu city of Shandong Province
10.3760/cma.j.issn.1008-6706.2014.21.001
- VernacularTitle:山东省莱芜市汉族女性5，10-亚甲基四氢叶酸还原酶与甲硫氨酸合成酶还原酶基因多态性研究
- Author:
Yuchan JIANG
;
Yanqiang LU
;
Ying LI
;
Xiaoling LIU
;
Qi YANG
- Publication Type:Journal Article
- Keywords:
5,10-methylenetetrahydrofolate reductase;
5-methyltetrahydrofolate-homocysteine methyltrans-ferase reductase;
Single nucleotide polymorphism
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(21):3201-3203
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the 5,10-methylenetetrahydrofolate reductase( MTHFR) and 5-methyltet-rahydrofolate-homocysteine methyltransferase reductase( MTRR) gene polymorphisms among the Han women in Laiwu City.Methods A total of 559 Han women were recruited.And their oral epithelial cells were collected to extract genome DNA in order to detect gene polymorphisms of MTHFR and MTRR using fluorescence quantitative PCR.Then the results were compared with those in other cities in China.Results The frequency of MTHFR 677CC,677CT and 677TT of Han women in Laiwu city was 14.3%,46.7%and 38.1%,respectively.The frequency of MTHFR 677TT among Laiwu women was significantly different to those of Zhenjiang, Wuhan, Kunming, Deyang, Huizhou, Qionghai (P<0.05).The frequency of AA,AC,CC gene type on MTHFR A1298C was 78.2%,19.7% and 2.1%,respec-tively, the frequency was significantly different to those of Zhenjiang, Wuhan, Kunming, Deyang, Huizhou, Qionghai (P<0.05).The frequency of AA,AG,GG gene type on MTRR A66G was 53.3%,38.8%and 7.9%,respectively. The frequency of MTRR 66GG was significantly different to that of Qionghai(P<0.05).Conclusion The MTHFR, MTRR polymorphism distribution of Han women in Laiwu City has the characteristic of region specificity,respectively.
