Effect of Montelukast combined with Beclomethasone in the treatment of pediatric asthma and the influence on the levels of serum IgE,IL-4 and TNF-α
10.3760/cma.j.issn.1008-6706.2014.21.017
- VernacularTitle:孟鲁司特联合丙酸倍氯米松治疗小儿哮喘的疗效及对血清免疫球蛋白 E、白细胞介素4和肿瘤坏死因子α水平的影响
- Author:
Jun LI
- Publication Type:Journal Article
- Keywords:
Asthma;
Montelukast;
Beclomethasonel;
Immunoglobulin E;
Interleukin-4;
Tumor Necrosis Fac-tor-alpha;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(21):3243-3245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of Montelukast combined with Beclomethasone in the treatment of asthma and the influence on the levels of serum immunoglobulin E(IgE),interleukin 4(IL-4) and tumor necrosis factor alpha ( TNF-α) .Methods 88 children with pediatric asthma were divided into the two groups according to random number table method,44 cases were in each group.The control group was only treated with Beclomethasone, once a day,while the observation group was treated with Montelukast combined with Beclomethasone,10mg,once a day,last for 3 months.The levels of serum IgE,IL-4 and TNF-αof the two groups before and after treatment was observed.The clinical effective rate and adverse reactions were evaluated.Results After the treatment,the levels of serum IgE,IL-4 and TNF-αof the two groups were significantly lower than those before treatment ( t=2.21,2.44, 2.21,9.61,9.02,9.61,all P<0.05);The clinical total effective rate of the observation group was 93.18%,which was obviously higher than 72.73%of the control group(χ2 =6.51,P<0.05);The adverse reactions of the control group and observation group was 3 cases(6.82%),6 cases(13.64%),respectively,the symptom was lighter,there was no statistical significance of the incidence of adverse drug reactions(χ2 =1.11,P>0.05).Conclusion There was good curative effect and security of Montelukast and Beclomethasone in the treatment ofasthma,which significantly reduced the levels of serum IgE,IL-4 and TNF-αand inhibited the action of the airway chronic inflammation.
