Chromosomal analysis of 394 couples with recurrent spontaneous abortion
10.3969/j.issn.1673-4130.2015.01.020
- VernacularTitle:394对复发性自然流产夫妇染色体核型分析
- Author:
Jingjing WANG
;
Yunduan WANG
;
Xiquan CHEN
;
Zhicheng HUANG
- Publication Type:Journal Article
- Keywords:
recurrent spontaneous abortion;
chromosome;
abnormal karyotype
- From:
International Journal of Laboratory Medicine
2015;(1):49-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between recurrent spontaneous abortion and the chromosome abnormality by analyzing the 394 couples′chromosome karyotypes.Methods Peripheral blood lymphocytes in 394 couples of recurrent spontane-ous abortion in Guangzhou area were cultured and performed the chromosome karyotype analysis.Results Among 394 couples of recrudescence abortion,41 cases (5.2%)of abnormal chromosome karyotypes were detected including 1 case(2.44%)of chromo-some number abnormality,8 cases (19.51 %)of balanced translocation,3 cases (7.32%)of Robertsonian translocation,1 case (2.44%)of chromosome inversion and 28 cases (68.29%)of chromosomal polymorphism.Conclusion The chromosomal abnor-mality is an important reason for recurrent spontaneous abortion.Recurrent spontaneous abortion is not only associated with anoma-lies of chromosome structure,and could have a certain relationship with chromosome polymorphism.
