Research on effect of clopidogrel on platelet VASP phosphorylation level after PCI operation
10.3969/j.issn.1673-4130.2015.01.017
- VernacularTitle:PCI 术后氯吡格雷影响血小板 VASP 磷酸化水平的研究
- Author:
Wei ZHAO
;
Shaohua SUN
;
Guangbin QIU
- Publication Type:Journal Article
- Keywords:
flow cytometry;
acute coronary syndrome;
clopidogrel;
platelet;
vasodilator-stimulated phosphoprotein
- From:
International Journal of Laboratory Medicine
2015;(1):42-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To use the flow cytometry to detect the platelet vasodilator-stimulated phosphoprotein(VASP)phospho-rylation level and to evaluate the clopidogrel curative effect after PCI.Methods 17 cases in the control group without any drug in-tervention and 26 cases of acute coronary syndrome(ACS)after PCI operation with clopidogrel were selected.Platelet VASP phos-phorylation levels at being selecting and on 7 d after anti-platelet therapy were detected by the flow cytometry and the platelet reac-tivity index (PRI)was calculated.Results The PRI after anti-platelet therapy in the ACS group was decreased significantly,the difference between before treatment and after treatment had statistical significance (P <0.05 ).Conclusion The platelet VASP phosphorylation level detected by the flow cytometry can specifically evaluate the effect of clopidogrel.
