Study on the relationship between pregnancy-induced hypertension and serum levels of homocysteine,folic acid,vitamin B12
10.3969/j.issn.1673-4130.2014.21.003
- VernacularTitle:孕妇血清同型半胱氨酸、叶酸、维生素B12水平与妊娠高血压综合征关系探讨
- Author:
Hua HUANG
;
Hongmei LIANG
;
Qizhi LUO
;
Qun CHEN
;
Wenshen LUO
;
Yuanru WU
;
Hongxia BAO
;
Xiaomin WANG
;
Yunhua WAN
- Publication Type:Journal Article
- Keywords:
homocysteine;
pregnancy induced hypertension syndrome;
folic acid;
vitamin B12;
early pregnancy;
mid-dle pregnancy;
late pregnancy
- From:
International Journal of Laboratory Medicine
2014;(21):2869-2871
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study on the relationship between the levels of homocysteine(HCY) ,folic acid and vitamin B12 and pregnancy-induced hypertension(PIH) in different pregnancies .Methods 539 pregnant women who registered for prenatal exami-nation of pregnant in the hospital were selected as research subjects .And there were 87 cases of PIH(PIH group) and 452 cases of normal pregnancy(normal pregnancy group) among them .The fasting blood samples were collected respectively in early pregnancy (8-10 weeks and 12-14 weeks of pregnancy) ,mid pregnancy(18 pregnancy weeks and 24 pregnancy weeks) ,and late pregnancy (30 pregnancy weeks and 36 pregnancy weeks) ,and the levels of HCY ,folic acid and vitamin B12 were measured .At the same time ,the supplements of folic acid and vitamin B12 and the incidence of PIH and birth defects were asked ,registered and checked . Results Compared with normal pregnancy group ,the serum HCY level of PIH group significantly increased in medium and late pregnancy periods (P<0 .05) ,and had no statistical significance in early pregnancy(P>0 .05) .In mid and late pregnancy periods , the serum HCY levels of PIH group and normal pregnant group negatively correlated with serum folic acid levels (r<0 ,P<0 .05) , and did not correlate with vitamin B12 levels (P>0 .05) .Conclusion In middle and late pregnancy periods ,if the serum HCY level of pregnant women increased ,the risk of PIH increased significantly .
