Meta analysis for the association between a genetic variant in gene Dicer and cancer susceptibility
10.3969/j.issn.1673-4130.2014.21.004
- VernacularTitle:Dicer基因多态性与肿瘤易感性的meta分析
- Author:
Hui ZENG
;
Tuo ZENG
;
Xinghua LONG
- Publication Type:Journal Article
- Keywords:
Dicer gene;
gene polymorphism;
cancer;
meta analysis
- From:
International Journal of Laboratory Medicine
2014;(21):2872-2874
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between a genetic variant in Dicer and cancer risk .Methods Both English and Chi-nese databases were carefully searched comprehensively .Based on the including and excluding criteria ,literatures that were eligible were carefully screened and data were retrieved .Meta analysis was performed by RevMan 5 .1 software .Pooled odds ratios(OR) and 95% confi-dential interval(CI)were used for analysis .Results Ten eligible literatures were included in the meta analysis .Meta analysis showed that the mutant allele C in 3′untranslated region polymorphism loci rs1057035 of Dicer gene might reduce the cancer risk(OR=0 .92 ,95% CI=0 .87-0 .97 ,P=0 .003) .Conclusion The variant rs1057035 T>C in Dicer gene could be related to cancer susceptibility .
