The application of plasma D-dimer in the diagnosis of spontaneous peritonitis in cirrhotic patients with ascites
10.3969/j.issn.1673-4130.2014.21.008
- VernacularTitle:血浆D-二聚体检测在诊断肝硬化腹腔积液患者自发性细菌性腹膜炎中的应用
- Author:
Weiyi XU
;
Baode CHEN
;
Qing XU
- Publication Type:Journal Article
- Keywords:
D-dimer;
C-reactive protein;
cirrhosis;
peritonitis
- From:
International Journal of Laboratory Medicine
2014;(21):2883-2884
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of plasma D-dimer(D-D )in the diagnosis of spontaneous bacterial per-itonitis(SBP)in patients with liver cirrhosis .Methods 137 cases of cirrhotic patients with ascites were selected and divided into SBP group and non SBP(NSBP) group .30 cases of patients with chronic liver disease and 30 healthy individuals were selected as chronic liver disease group and normal control group ,respectively .The levels of D-D and C-reactive protein(CRP) were measured in specimens from all the groups .Results The D-D levels of SBP group ,NSBP group ,chronic liver disease group and normal control group were (7 .82 ± 5 .68) ,(5 .55 ± 4 .55) ,(0 .45 ± 0 .26) and (0 .06 ± 0 .04) mg/L ,respectively .And the serum CRP levels were (30 .0 ± 29 .6) ,(16 .4 ± 20 .5) ,(5 .3 ± 1 .8) and (2 .1 ± 0 .9)mg/L ,respectively .The levels of D-D and CRP were both higher in SBP group and NSBP group than in chronic liver disease group and normal control group(P<0 .01) .The D-D and CRP levels of SBP group were both significantly higher than those of NSBP group (P<0 .05) .The ROC curve showed that the AUC ,sensitivity and specificity of D-D were 0 .650 ,0 .604 and 0 .709 ,respectively ,and those of CRP were 0 .705 ,0 .792 and 0 .582 ,respectively .Conclu-sion Plasma D-D detection was beneficial to the early diagnosis of SBP in cirrhotic patients with ascites .
