Research progress of DNA methylation in osteosarcoma
- VernacularTitle:DNA 甲基化与骨肉瘤关系的研究进展
- Author:
Xiaozhou LIU
;
Jianning ZHAO
;
Sujia WU
- Publication Type:Journal Article
- Keywords:
DNA methylation;
Osteosarcoma;
Tumor-related genes;
Diagnosis and treatment
- From:
Journal of Medical Postgraduates
2014;(10):1107-1110
- CountryChina
- Language:Chinese
-
Abstract:
The early diagnosis , the prediction of recurrence and metastasis of osteosarcoma and avoiding chemotherapy resist -ance play a key role in the therapeutic areas of osteosarcoma .DNA methylation is the main reason of activation of oncogene and inacti-vation of tumor suppressor gene .It has been proven that the methylation of multiple genes is closely related to clinical indicators and targeted therapy of osteosarcoma .It is expected that DNA methylation can be used for the clinical diagnosis and treatment of osteosarco -ma.In this paper, the relationship between DNA methylation and osteosarcoma is reviewed .
