Comparison of cerebral white matter fractional anisotropy and metabolite concentrations measured by 1 H-MRS in healthy adults
10.3969/j.issn.1002-1671.2014.10.003
- VernacularTitle:健康成人脑白质MRFA值与1H-MRS代谢物浓度相关性研究
- Author:
Sainan CHENG
;
Qiang LIU
;
Yubo Lü
;
Yuchao LI
;
Tao GONG
;
Yi ZHANG
- Publication Type:Journal Article
- Keywords:
diffusion tensor imaging;
magnetic resonance spectroscopy;
the white matter
- From:
Journal of Practical Radiology
2014;(10):1614-1617
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between cerebral white matter fractional anisotropy(FA)and metabolite con-centrations measured by 1 H magnetic resonance spectroscopy(1 H-MRS)in healthy adults.Methods Diffusion tensor imaging(DTI) and 1 H-MRS were acquired from thirty-one healthy adults at 3.0 T MR system.The concentrations of N-acetylaspartate(NAA), choline(Cho),creatine(Cr),the ratios of NAA/Cr and FA values of DTI were measured in 353 voxels,covering the bilateral medium corona radiata.According to the age,all voxels were divided into two groups:the senior group (mean age=29 years),and the senior group(mean age=5 6 years).The correlations between FA values and age were analyzed using Pearson’s correlation coefficients.The correlations between FA values and metabolite concentrations were estimated using partial correlations test controlling for the age re-lated bias.Results Pearson’s correlation analysis revealed a negative correlation between FA values and age in 353 voxels(r=-0.146,P<0.05),senior group(r=-0.204,P<0.05)and senior group(r=-0.162,P<0.05).Only the correlation between NAA and FA values were significant(r=0.339,P<0.05;r=0.213,P<0.05;r=0.430,P<0.05).There were positive relation-ships between FA values and NAA/Cr among 353 voxels (r=0.166,P<0.05)and senior group(r=0.305,P<0.05).Conclusion There are correlations between cerebral white matter FA values and metabolite concentrations measured by 1 H-MRS .Combining 1 H-MRS with DTI can reveal the relationship between microscopic white matter integrity and metabolic characteristics of the white matter.
