Research advances in the role of γδT cells in the pathogenesis of rheumatoid arthritis
10.3760/cma.j.issn.2095-428X.2014.21.002
- VernacularTitle:γδT细胞在类风湿性关节炎中的研究进展
- Author:
Wei ZHANG
;
Sha LI
- Publication Type:Journal Article
- Keywords:
γδT cells;
Rheumatoid arthritis;
Autoimmune disease
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(21):1604-1606
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis (RA) is a common systemic autoimmune disease characterized by chronic inflammation of joints,bone and cartilage erosion,synovial hyperplasia,and the pathogenesis of RA is not clear.γδT cells are a new kind of phenotype and function T lymphocyte subsets,which mainly distribute in the mucosal and epithelial tissue and account for 1％-10％ of the total T cells in the peripheral blood,and bridge innate and adaptive immunity.γδT cells play an important role in the pathogenesis of RA by the functions of antigen-presenting capacity,secretion of proinflammatory cytokines,immunomodulatory effects,and auxiliary function for B cells.
