Relationship Between Plasma Apelin and Angiotensin II With Hypertension and Hypertension Caused Early Renal Damage
10.3969/j.issn.1000-3614.2014.10.011
- VernacularTitle:血浆Apelin、血管紧张素Ⅱ与高血压及早期肾损害的相关性研究
- Author:
Lili ZHOU
;
Pengli ZHU
;
Fan LIN
;
Feng HUANG
;
Tong GAO
;
Falin CHEN
;
Jiangang HUANG
- Publication Type:Journal Article
- Keywords:
Apelin;
Hypertension;
Angiotensin II;
Renal damage
- From:
Chinese Circulation Journal
2014;(10):800-804
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship of plasma apelin and angiotensin II (Ang II) with hypertension and hypertension caused early renal damage in order to provide the information for hypertension treatment. Methods: A total of 671 participants were enrolled in this cross-sectional community investigation. All participants were above 30 years of age with local residency longer than 5 years and were divided into 2 groups: Control group,n=354 non-hypertension subjects and Hypertension group,n=317 patients with essential hypertension. The levels of apelin, Ang II, urine creatinine and urinary albumin were examined. The relationship between blood pressure and the ratio of urinary albumin to urine creatinine (UACR) and the relationship between blood pressure and apelin, Ang II were studied by Pearson correlation analysis and multi linear regression analysis. Results: Compared with Control group, Hypertension group had the lower levels of apelin and higher UACR, both P<0.01. The mean arterial pressure (MAP) was negatively related to Ln (apelin), positively related to Ln (Ang II), bothP<0.01. With adjusted gender, age and blood lipids, the above relationship still existed. In Hypertension group, the patients combining with the early renal damage had the lower level of apelin and higher level of Ang II, bothP<0.01. The relevant analysis indicated that Ln (UACR) was negatively related to Ln (apelin), positively related to Ln (Ang II), bothP<0.01. With adjusted gender, age, MAP and blood lipids, the above relationship still existed. Conclusion: The patients with hypertension or hypertension caused early renal damage have decreased apelin. Apelin is negatively related to Ang II, therefore, apelin might be used as a target for hypertension treatment in clinical practice.
