Effects of Different Extracts of Modified Siwu Siteng Decoction on Uric Acid and Xanthine Oxidase in Rats with Hyperuricemia
10.3969/j.issn.1005-5304.2014.11.020
- VernacularTitle:加味四物四藤汤不同提取物对大鼠血尿酸及黄嘌呤氧化酶的影响
- Author:
Xuefang YANG
;
Keli GAO
;
Yongchang WANG
;
Yongdong ZHANG
;
Hongyun GUO
;
Haixiang SU
- Publication Type:Journal Article
- Keywords:
modified Siwu Siteng Decoction;
hyperuricemia;
xanthine oxidase;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(11):66-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of different extracts of modified Siwu Siteng Decoction (TFT-Ⅰ, TFT-Ⅱ) on rat models with hyperuricemia. Methods Rat model with hyperuricemia was induced by hypoxanthine and oxonic acid potassium salt. Seventy rats were randomly divided into 7 groups:normal group, model group, allopurinol group, TFT-Ⅰ high and low dose groups, TFT-Ⅱhigh and low dose groups. Each dose group was given lavage with related medicine, and blank group and model group were given lavage with distilled water for one week, respectively. Uric acid in serum (SUA) was measured through fully automatic biochemical analyzer, and xanthine oxidase (XOD) activity in serum and liver tissue was measured through colorimetric method. Results Compared with model group, TFT-Ⅰ and TFT-Ⅱ high dose groups significantly reduced the level of SUA, serum and liver XOD activity (P<0.05), with significant statistical difference between the two groups (P<0.05). TFT-Ⅰ and TFT-Ⅱ low dose groups had no significant effects on SUA, and XOD activity in serum and liver (P>0.05). Conclusion Alcohol soluble ingredients of astragalus membranaceus and Siwu decoction in modified Siwu Siteng Decoction can effectively reduce the level of blood uric acid.
