Correlation between mechanical pain threshold and local blood perfusion in male rat models of acute inflammation induced by carrageenan
10.3969/j.issn.1671.7856.2014.010.013
- VernacularTitle:角叉菜胶致急性痛雄性大鼠机械痛阈与局部血流量的相关性
- Author:
Jing SUN
;
Xiaomei SHAO
;
Fang FANG
;
Zui SHEN
;
Jianqiao FANG
- Publication Type:Journal Article
- Keywords:
Carrageenan;
Acute inflammatory pain;
Local blood perfusion;
Correlation;
SD Rats
- From:
Chinese Journal of Comparative Medicine
2014;(10):67-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between mechanical withdrawal threshold ( MWTs) and local cutaneous blood perfusion ( BP ) in rats with acute inflammation induced by carrageenan.Methods Twenty male Sprague-Dawley ( SD) rats were randomly divided into control and model groups.The acute inflammatory rat model was established by subcutaneously injecting with carrageenan into the left hindpaw.MWTs were measured by Dynamic Plantar Aesthesiometer 37450 before injection ( as base) of carrageenan and at 4 h, 24 h, 48 h, 72 h after carrageenan injection. The local cutaneous BP was detected by Pericam Perfusion Speckle Imager ( Pericam PSI) at the time after measuring of MWTs.The above two behaviors were compared and the relationship between them was analyzed.Results MWTs of the model group rats were decreased while BP significantly increased than that in the control group ( P<0.01 ) .The MWTs and BP in the model rats showed a negative correlation, especially the correlation index showed significant differences at 4 h and 72 h after carrageenan injection ( P<0.01) .Conclusions Carrageenan-induced acute inflammation in rats causes significant changes in mechanical pain threshold, which has a negative correlation with local cutaneous blood perfusion.
