Effect of continuous blood purification on immune function and prognosis in patients with severe sepsis
10.3969/j.issn.1006-5725.2014.17.012
- VernacularTitle:连续性血液净化对脓毒症患者免疫功能及预后的影响
- Author:
Suzhen FU
;
Jie SUN
;
Yun DONG
;
Qi ZHAO
;
Bingxing GUAN
- Publication Type:Journal Article
- Keywords:
Sepsis;
Continuous blood purification;
Th1 / Th2;
Prognosis
- From:
The Journal of Practical Medicine
2014;(17):2731-2734
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of continuous blood purification (CBP) on pro-or anti-inflammatory immune function and prognosis in patients with sepsis. Methods One hundred and two patients with sepsis were randomized into the CBP group (60 cases) and the control group (42 cases). The patients in the control group were treated with conventional therapy, and the patients in the CBP group received at least 72 h CBP treatment additionally. The APACHEⅡ score, SOFA score, the 28 day survival rate and ICU length of stay were recorded and levels of spleen Th1, Th2 were assessed by FACS flow cytometry. Enzyme linked immunoadsordent assay (ELISA) was used to determine the levels of serum IL-1, IL-10 and TNF-α before and at 24, 48, 72 h after the treatment. Results The APACHEⅡscore and SOFA score decreased markedly in the CBP group after the treatment (Р <0.05). The period of staying in ICU of patients in the CBP group was shorter than that of patients in the control group (Р < 0.05). There was no significant difference of the 28 day survival rate between the two groups (91.6% vs 71.2%, Р > 0.05). Compared with the control group, levels of IL-1, IL-10 and TNF-α were decreased markedly, and the ratio of Th1 / Th2 was increased significantly at 72 h after the treatment in the CBP group (Р < 0.05). Conclusion CBP can eliminate inflammatory mediators, and help to enhance the immune function, and restore the balance of Th1 / Th2 in patients with severe sepsis.
