Expressions of OPN, COX-2 and CyclinD1 in breast infiltrating carcinoma and their relationship with clinicopathological features
10.3969/j.issn.1006-5725.2014.17.013
- VernacularTitle:乳腺浸润癌组织中骨桥蛋白、环氧化酶-2和细胞周期素 D1的表达及其意义
- Author:
Hua HAO
;
Fen XU
;
Liqing WU
;
Lixiang LI
;
Lei ZENG
;
Xinxin ZHANG
;
Dan GONG
;
Yuqing YANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
OPN;
COX-2;
CyclinD1
- From:
The Journal of Practical Medicine
2014;(17):2734-2736
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expressions of OPN, COX-2 and CyclinD1 in breast infiltrating carcinoma and evaluate their relationships with clinic pathological features. Methods Expression of the above three indexes were detected from 70 breast cancinoma patients by immunohistochemistry. The relationships among them and clinicopathological features were analyzed. Results The positive expression rates of OPN were 78.8% in cases (≤45 years old) and 73.0% in cases (> 45 years old); the positive expression rates were 79.3%(tumor diameter ≤ 3 cm) and 73.2% (tumor diameter > 3 cm); the positive expression rates were 77.8%, 73.8% and 78.9% in cases ofⅠgrade, Ⅱgrade and Ⅲ respectively, the positive rates had no statistical significances(P > 0.05). The expression rates of OPN in cases of breast infiltrating carcinoma without and with axillary node metastasis were 62.5% and 93.3%, in cases at stage Ⅰ~Ⅱ and Ⅲ ~Ⅳ were, 68.0% and 95.0% respectively, the positive rates had statistical significances(P < 0.05). The expression of OPN was negatively correlated with ER and PR while positively correlated with CerbB2, COX-2 and CyclinD1. Conclusions OPN plays an important role in the invasion and metastasis of breast carcinoma coordinated with COX-2 and CyclinD1.
